Research success in the diabetes treatment

Researchers of the University of Zurich developed a therapy against the sugar illness, which fights not only the symptoms, but the causes against diabetes type 2.

With the successful testing of the therapy at patients hope for easement exists for humans, who suffer from this “Volkskrankheit”.



Artificially do not only add insulin, but the body-own production of the material again set in motion: The fact that this is possible proved researchers of the University of Zurich. It is a break-through in the treatment of diabetes 2.

Today diabetes 2 is the Volkskrankheit number 1. The designation “age diabetes” still common in the vernacular is an outdated term, as the physician and researcher implemented Marc Donath on Thursday. Ever more are affected also young people and children by it.

The illness develops usually as consequence of predominance. The insulin-producing cells must work ever more, until they finally fail and die. The blood sugar household regulated by the insulin turns out now completely from the equilibrium. It must be admitted artificially insulin. The illness is chronic and constantly worsens.


A cause fight



Donath and its group of researchers at the University of Zurich succeeded it now to find a method which fights the cause of the disturbed insulin household. The study is published in the renowned technical periodical “new England journal OF Medicine”.

“Until today we could decrease only the blood sugar values without we the evil of the illness at the root meet could. We could not block also a progressing of the diabetes”, said opposite to Donath swissinfo.

The researching identified the molecule Interleukin-1ss as mediators of the cell failure. Then they investigated, how this mechanism can be interrupted. Attempts with diabetes patients of many years showed that the influence of the Interleukin-1ss on the cells can be blocked with an appropriate medicine effectively and well compatibly.

Thus progressing the illness could be braked for the first time. The cells produced again more and qualitatively better insulin. The blood sugar values of the treated patients improved already after one week clearly. At the group of comparisons, which received only active substanceless placebo, they worsened accordingly the normal disease process.

At the same time with the improvement of the diabetes to different subsequent diseases as cardiovascular diseases one prevents.

The realization is a break-through in the treatment of diabetes 2. Meanwhile long-term blocker developed - which might come however only into a few years on the market - to make possible according to Donath a treatment with a syringe every few weeks. Today still another daily medicine income or injection is necessarily.


Further studies intended



Resuming studies are necessary according to Donath, in order to find out, whether do not only decrease diabetes 2, but actually heal leave. However: Even if the cells produced again completely normally insulin, only healthy life-style with much movement could prevent a returning of the illness.

Follow-up studies are besides to show whether also diabetes 1 can be treated with the same active substance as diabetes 2, which is the by far more frequent kind: From all diabetes patients - in Switzerland there is approximately 500 ' 000 - 90% from the type 2 suffers.

For Donath it will give “within three to five years changes with the therapy of diabetes”.

A cause for cancer of the breast discovers

The diseased Vermehrung of a gene contributes to the emergence of cancer of the breast, as German scientists found out.

The investigation of Gewebsproben could increase additionally to the mammography the early recognition.
German new generation researchers found an important cause for the emergence of cancer of the breast. The discovery patented meanwhile supplies reference points for a safer cancer of the breast diagnosis and a better treatment of a kind of this illness, reported the university clinic Hamburg Eppendorf on Tuesday.

It concerns the diseased Vermehrung of certain genes with cancer of the breast. The graduate students Frederik get and to Phillip steel from the team of Ronald Simon of the university clinic its work in the expenditure for on-line of the journal “Nature Genetics” published.

Since longer it is well-known that diseased Vermehrungen gene amplifications so by genes, mentioned, with which emergence of cancer of the breast plays a role. By investigations at fabric samples of more than 2,000 female patients the researchers found out now that in more than 20 per cent of the cases the gene ESR1 is present several times.
More purposeful therapy

By the gene ESR1 a protein one code, which binds the female sex hormone Östrogen, the Östrogen receptor in such a way specified. The excessive formation of the Östrogen receptor is one of the most important well-known causes for the emergence of cancer of the breast. Therefore the Östrogen receptor to time the most important attack target of the medicamentous therapy is. Östrogen receptor amplification in can be already proven in good-like fabric changes and be such a first indication for a cancer illness beginning. That would make an earlier, more purposeful and more effective therapy possible.

In a second study the Wissenschafter evaluated therefore the data and fabric samples of 175 breast cancer patients, who had been treated with the active substance Tamoxifen directed against the Östrogen receptor. It determined that those female patients, with whom a ESR1-Amplifikation was appropriate for the excessive formation of the Östrogen receptor to reason responded particularly well to the therapy.

If the Vermehrung of the gene proves even with further breast cancer patients than a cause, surface covering standard investigations could be introduced with each again discovered cancer of the breast.