Researchers of the University of Zurich developed a therapy against the sugar illness, which fights not only the symptoms, but the causes against diabetes type 2.
With the successful testing of the therapy at patients hope for easement exists for humans, who suffer from this “Volkskrankheit”.
Artificially do not only add insulin, but the body-own production of the material again set in motion: The fact that this is possible proved researchers of the University of Zurich. It is a break-through in the treatment of diabetes 2.
Today diabetes 2 is the Volkskrankheit number 1. The designation “age diabetes” still common in the vernacular is an outdated term, as the physician and researcher implemented Marc Donath on Thursday. Ever more are affected also young people and children by it.
The illness develops usually as consequence of predominance. The insulin-producing cells must work ever more, until they finally fail and die. The blood sugar household regulated by the insulin turns out now completely from the equilibrium. It must be admitted artificially insulin. The illness is chronic and constantly worsens.
A cause fight
Donath and its group of researchers at the University of Zurich succeeded it now to find a method which fights the cause of the disturbed insulin household. The study is published in the renowned technical periodical “new England journal OF Medicine”.
“Until today we could decrease only the blood sugar values without we the evil of the illness at the root meet could. We could not block also a progressing of the diabetes”, said opposite to Donath swissinfo.
The researching identified the molecule Interleukin-1ss as mediators of the cell failure. Then they investigated, how this mechanism can be interrupted. Attempts with diabetes patients of many years showed that the influence of the Interleukin-1ss on the cells can be blocked with an appropriate medicine effectively and well compatibly.
Thus progressing the illness could be braked for the first time. The cells produced again more and qualitatively better insulin. The blood sugar values of the treated patients improved already after one week clearly. At the group of comparisons, which received only active substanceless placebo, they worsened accordingly the normal disease process.
At the same time with the improvement of the diabetes to different subsequent diseases as cardiovascular diseases one prevents.
The realization is a break-through in the treatment of diabetes 2. Meanwhile long-term blocker developed - which might come however only into a few years on the market - to make possible according to Donath a treatment with a syringe every few weeks. Today still another daily medicine income or injection is necessarily.
Further studies intended
Resuming studies are necessary according to Donath, in order to find out, whether do not only decrease diabetes 2, but actually heal leave. However: Even if the cells produced again completely normally insulin, only healthy life-style with much movement could prevent a returning of the illness.
Follow-up studies are besides to show whether also diabetes 1 can be treated with the same active substance as diabetes 2, which is the by far more frequent kind: From all diabetes patients - in Switzerland there is approximately 500 ' 000 - 90% from the type 2 suffers.
For Donath it will give “within three to five years changes with the therapy of diabetes”.
